It truly is tricky to decide what constitutes a regular harmful or lethal dose. However, the lethal oral dose of codeine within an Grownup is documented for being within the range of 0.

It really is unidentified if this medication passes into breast milk. Nevertheless, it could possibly have unwanted outcomes with a nursing infant. Consult your physician prior to breastfeeding.

Place the mixture in a very container like a sealed plastic bag and throw it absent inside the home trash. It's also possible to stick to your state or nearby guidelines regarding how to safely throw absent Promethazine Hydrochloride and Codeine Phosphate Oral Resolution.

Stay away from the usage of Promethazine HCl and Codeine Phosphate Oral Alternative in adolescents twelve to eighteen years of age who have other danger factors that could improve their sensitivity to the respiratory depressant consequences of codeine.

Narcotics could generate adverse reactions which can obscure the clinical system of sufferers with head accidents.

Codeine was not mutagenic inside the in vitro bacterial reverse mutation assay or clastogenic within the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.

Stay away from the use of Promethazine HCl and Codeine Phosphate Oral Solution in adolescents twelve to eighteen many years of age who have other threat elements that will maximize their sensitivity towards the respiratory depressant results of codeine. Risk elements contain situations affiliated with hypoventilation, such as postoperative position, obstructive snooze apnea, being overweight, extreme pulmonary illness, neuromuscular condition, and concomitant usage of other remedies that lead to respiratory depression.

Usually do not flush drugs down the bathroom or pour them right into a drain Except if instructed to take action. Effectively discard this merchandise when it is expired or not essential. Consult your pharmacist or local squander disposal corporation.

This could certainly take place even if you take Promethazine Hydrochloride and Codeine Phosphate Oral Remedy particularly as prescribed by your Health care supplier. Your possibility of dependancy, abuse, and misuse is enhanced in case you or maybe a relative has a heritage of drug or alcohol abuse or habit, or psychological health problems.

Promethazine has an elimination half-life of 10-14 hrs, with excretion of metabolites showing while in the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine would be the predominant metabolites showing in the urine.

Due to the fact opioid agonists may possibly boost biliary Promethazine codeine syrup tract stress, with resultant rise in plasma amylase or lipase amounts, perseverance of these enzyme ranges may be unreliable for twenty-four hours soon after administration of a dose of Promethazine HCl and Codeine Phosphate Oral Resolution.

Postmarketing scenarios of respiratory despair, which include fatalities have been documented with usage of promethazine in pediatric patients.

Codeine is known to generally be significantly excreted via the kidney, and the chance of adverse reactions to this drug could possibly be higher in people with impaired renal purpose.

The treatment of overdosage with promethazine and codeine is actually symptomatic and supportive. Only in instances of extreme overdosage or person sensitivity do essential indicators together with respiration, pulse, blood pressure, temperature, and EKG should be monitored. Activated charcoal orally or by lavage may very well be supplied, or sodium or magnesium sulfate orally like a cathartic. Interest need to be supplied for the reestablishment of ample respiratory Trade through provision of the patent airway and establishment of assisted or controlled ventilation.